Predictive value of Albumin-Bilirubin grade for intravenous immunoglobulin resistance in a large cohort of patients with Kawasaki disease: a prospective study

Table 3 Sensitivity, specificity, PPV, NPV, diagnostic accuracy of ALBI, ALB, and TBil cut-off values in initial IVIG resistance prediction

	AUC	SE	95 %CI	Sensitivity	Specificity	PPV	NPV	Diagnostic accuracy	p value
ALBI≥-2.57	0.705	0.0277	0.672–0.736	0.617	0.657	0.226	0.914	0.651	< 0.001
ALB ≤ 33.0 g/L*	0.659	0.0281	0.626–0.692	0.374	0.850	0.289	0.893	0.783	< 0.001
TBil ≥ 16.0µmol/L*	0.626	0.0305	0.592–0.659	0.269	0.941	0.425	0.888	0.847	< 0.001

Abbreviations: ALB serum albumin; TBil, total bilirubin; ALBI = 0.66×log₁₀^TBil-0.085×ALB; IVIG intravenous immunoglobulin; NPV negative predictive value; PPV, positive predictive value
Pairwise comparison of ROC curves between ALBI and ALB, TBil in predicting IVIG resistance by De Long test, p = 0.001 and 0.012

ISSN: 1546-0096