Fig. 4

Hub gene identification and diagnosis prediction analysis. A Networks of the six hub genes identified by “cytoHubba” between RF-negative pJIA and healthy individuals. The yellow-to-red color scale denotes the p-value calculated by the MCC method. B Networks of the six hub genes identified by “cytoHubba” between oJIA and healthy individuals. The yellow-to-red color scale denotes the p-value calculated by the MCC method. C Diagnostic utility of the six hub genes in the GSE20307 datasets between RF-negative PJIA and healthy individuals. D Diagnostic utility of the six hub genes in the GSE20307 datasets between oJIA and healthy individuals