Fig. 3

Relationship between CNS biomarkers and disease activity in juvenile idiopathic arthritis (JIA) patients, categorized by JADAS27 scores. (a) Analysis shows a significant increase in astrocyte-derived EV levels in patients with higher disease activity (JADAS27 scores above 1). (b) There is a comparable significant relationship for S100B protein concentrations, with higher disease activity (scores above 1) correlating with elevated levels. Red line indicates mean