Table 2 Laboratory and pathological examination of Chinese children with HNL at the onset of the first episode, stratified by recurrence status
Variables | Total (n = 181) | Non-recurrent HNL (n = 158) | Recurrent HNL (n = 23) | P value |
|---|---|---|---|---|
Complete blood count, n (%) | ||||
Leukopenia (WBC < 4 × 109/L) | 120 (66.3%) | 111 (70.3%) | 9 (39.1%) | 0.003 |
Anemia (Hb < 110 g/L) | 50 (27.6%) | 42 (26.6%) | 8 (34.8%) | 0.411 |
Thrombocytopenia (PLT < 100 × 109/L) | 5 (2.8%) | 5 (3.2%) | 0 | 0.387 |
Inflammatory markers, n (%) | ||||
CRP > 10 mg/L | 53 (29.3%) | 46 (29.1%) | 7 (30.4%) | 0.897 |
ESR > 30 mm/h | 106 (58.6%) | 86 (54.4%) | 20 (87.0%) | 0.003 |
LDH > 300 U/L, n = 170 | 149 (87.6%) | 130 (87.8%) | 19 (86.4%) | 0.845 |
SF > 500ng/ml, n = 124 | 30 (24.2%) | 25 (23.6%) | 5 (27.8%) | 0.701 |
Positive autoantibodies, n (%) | ||||
ANA, n = 162 | 15 (9.3%) | 14 (9.9%) | 1 (4.8%) | 0.446 |
RF-IgM, n = 110 | 24 (21.8%) | 21 (22.1%) | 3 (20.0%) | 0.854 |
RF-IgA, n = 110 | 11 (10.0%) | 10 (10.5%) | 1 (6.7%) | 0.643 |
Anti-RA33-IgG, n = 113 | 15 (13.3%) | 12 (12.2%) | 3 (20.0%) | 0.410 |
Pathological findings, n (%) | ||||
Necrosis | 181 (100%) | 158 (100%) | 23 (100%) | NA |
Histiocytosis | 181 (100%) | 158 (100%) | 23 (100%) | NA |
Positive CD68 | 181 (100%) | 158 (100%) | 23 (100%) | NA |
Positive CD123 | 153 (91.7%) | 133 (91.1%) | 20 (95.2%) | 0.731 |