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Table 4 Association between baseline levels of peripheral T-cells and cytokines and treatment changes during follow-up

From: Peripheral blood regulatory T cells and disease activity, quality of life, and outcomes in children with juvenile idiopathic arthritis

 

OPTIMISATION

INTENSIFICATION

 

HR (95% CI)

p value

HR (95% CI)

p value

Tregs

0.76 (0.53; 1.11)

0.140

1.03 (0.73; 1.44)

0.882

Th1 cells

1.06 (0.91; 1.22)

0.455

1.00 (0.84; 1.19)

0.989

Th2 cells

0.74 (0.48; 1.13)

0.162

1.19 (0.95; 1.47)

0.128

IFN-γ

1.02 (0.95; 1.09)

0.659

1.00 (0.92; 1.08)

0.997

IL-6

1.01 (0.99; 1.03)

0.454

0.99 (0.94; 1.04)

0.687

IL-4

0.84 (0.60; 1.19)

0.319

1.08 (0.79; 1.49)

0.621

IL-10

0.92 (0.81; 1.05)

0.223

0.99 (0.87; 1.14)

0.928

TGF-β

0.79 (0.64; 0.98)

0.031

1.03 (0.84; 1.25)

0.812

  1. Optimisation: reduction or cessation of glucocorticoids, disease-modifying drugs, or biological therapy; Intensification: intra-articular injections; increase or initiation of glucocorticoids, disease modifying drugs, or biological therapy
  2. CI: confidence interval; HR: hazard ratio; IFN-γ: interferon gamma; IL: interleukin; TGF-β: transforming growth factor beta; Th: T helper; Tregs: regulatory T cells
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Pediatric Rheumatology

ISSN: 1546-0096