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Fig. 3 | Pediatric Rheumatology

Fig. 3

From: Screening for comorbid autoimmune disease should be considered in children with ANA positive juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort

Fig. 3

Hazard ratios for comorbid autoimmune disease in juvenile idiopathic arthritis (JIA) depending on disease characteristics. Conditional Cox proportional hazard regression models with hazard ratios (HR) and 95% confidence interval (CI) within the first 7 years after JIA diagnosis for the autoimmune conditions: hypothyroidism, thyrotoxicosis, autoimmune thyroiditis, coeliac disease, type 1 diabetes mellitus, vitiligo, or alopecia areata, stratified on the basic disease characteristics; age at JIA diagnosis, male sex, antinuclear antibodies (ANA) positivity, and treatment with disease-modifying antirheumatic drug (DMARD) within the following calendar year after JIA diagnosis. The bars illustrate the 95% CIs with markers for HR. Number of individuals with comorbid autoimmune disease in the different analyses were in the JIA cohort; 17 in the total cohort, 3 in the male subgroup, 14 in the ANA positive subgroup, and 11 in the subgroup treated with any DMARD within the following calendar year after JIA diagnosis. In individuals with JIA, ANA positivity was associated with a significantly increased risk of a comorbid autoimmune disease

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Pediatric Rheumatology

ISSN: 1546-0096