Fig. 5

Hazard ratios for comorbid hypothyroidism in juvenile idiopathic arthritis (JIA) compared to references. Hazard ratios (HR) with 95% confidence interval (CI) for hypothyroidism within the first 7 years after JIA diagnosis using conditional Cox proportional hazard regression models. In all analyses, the individuals in the JIA cohort were compared to age- and sex matched references without JIA. Associations with hypothyroidism were calculated in the four subgroups; individuals belonging to antinuclear antibodies (ANA) positive JIA, ANA negative JIA, ANA positive JIA with onset before the age of six, and JIA with treatment with any disease-modifying antirheumatic drug (DMARD) within the following calendar year after JIA diagnosis. The bars illustrate the 95% CIs with markers for HR. Number of individuals with comorbid hypothyroidism in the different analyses were in the JIA cohort; 5 in the total cohort, 3 in the female subgroup, 4 in the ANA positive subgroup, 1 in the ANA negative subgroup, and 2 in the subgroup treated with any DMARD. Corresponding numbers were in the reference population; 6 in the total cohort, 6 in the female subgroup, 1 in the reference subgroup to ANA positive disease, 5 in the reference subgroup to ANA negative disease, and 2 in the reference subgroup to treatment with any DMARD. Data on hypothyroidism in males as well as ANA positive disease with onset before the age of six are not presented as there were too few events (n = 2 and 0, respectively) for these subgroup analyses. Significant differences were found in the total JIA population, and in the subgroup of individuals with ANA positive JIA