Table 2 Factors affecting growth and development in JIA
From: Endocrine dysfunction in patients with juvenile idiopathic arthritis
Parameters | Height for age | Weight for age | BMI for age | ||||||
|---|---|---|---|---|---|---|---|---|---|
Normal | Short | p- value | Underweight | Normal | p-value | Normal | Low | p- value | |
Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | ||||
Age of onset (years) | 10.6 (3.8) | 8.9 (3.0) | 0.015* | 9(4) | 10.6 (3.6) | 0.065 | 10.3(4) | 9.9(3) | 0.336 |
Disease duration (months) | 32 (20) | 38 (35) | 0.901 | 44(32) | 30(20) | 0.047* | 30(21) | 44(29) | 0.012* |
Duration of GC use (months) | 3.8 (8.0) | 7.6 (16.6) | 0.629 | 8.1(16) | 3.6(7.9) | 0.321 | 3.6(8) | 7.7 (15.2) | 0.368 |
Cumulative GC dose (mg) | 493.3 (937.4) | 877.0 (2094.3) | 0.686 | 1014.2 (2056.1) | 444.4 (891.7) | 0.406 | 466.8 (966.8) | 884.4 (1872.2) | 0.432 |
NSAIDs score | 32.22 (28.19) | 20.02 (18.07) | 0.064 | 24.41(19.13) | 31.24 (28.57) | 0.470 | 29.18 (27.57) | 31.28 (24.89) | 0.504 |
PGA | 4.4(2.4) | 4.2(2.4) | 0.846 | 4.9(2.5) | 4.2(2.4) | 0.175 | 4.1(2.4) | 4.9(2.3) | 0.141 |
PhGA | 4(2) | 3(2) | 0.389 | 4(2) | 3(2) | 0.284 | 3(2) | 4(2) | 0.107 |
JADAS27 | 12.7 (8.4) | 12.1 (8.6) | 0.603 | 14.9(10.6) | 11.9 (7.6) | 0.378 | 11.3 (7.4) | 16.4 (10.1) | 0.029* |
JADAS-CRP | 12(8) | 10.7 (7.6) | 0.478 | 14.1(9.6) | 11.1 (7.3) | 0.259 | 10.8 (7.3) | 14.6 (9.1) | 0.092 |
JADI-A | 2(5) | 2(4) | 0.273 | 3(4) | 2(5) | 0.090 | 2(4) | 4(7) | 0.013* |
JADI-E | 0(1) | 1(1) | 0.193 | 1(1) | 0(1) | 0.006* | 0(1) | 1(1) | 0.001* |
PRQoL | 9(6) | 9(6) | 0.988 | 11(6) | 8(5) | 0.079 | 8(5) | 11(6) | 0.008* |
Physical domain | 5(4) | 5(4) | 0.363 | 6(3) | 5(4) | 0.084 | 4(3) | 6(4) | 0.009* |
Mental domain | 4(3) | 4(2) | 0.248 | 5(3) | 4(2) | 0.083 | 4(2) | 5(2) | 0.019* |
CHAQ | 0.66 (0.52) | 0.53 (0.38) | 0.371 | 0.74(0.52) | 0.60 (0.49) | 0.238 | 0.56 (0.45) | 0.84 (0.58) | 0.023* |
Pain-VAS | 42(25) | 37(25) | 0.502 | 45(26) | 40(25) | 0.281 | 39(25) | 46(23) | 0.223 |
ESR | 43 (33) | 46 (35) | 0.764 | 46(37) | 43(32) | 0.872 | 38(29) | 58(40) | 0.029* |
CRP | 27.3 (28.4) | 22.3 (24.8) | 0.706 | 28.6(29.3) | 25.6 (27.3) | 0.720 | 24.9 (28.1) | 30.1 (26.3) | 0.298 |
GH (mIU/L) | 7.82 (11.04) | 10.71 (10.79) | 0.017* | 9.31(10.4) | 8.15 (11.22) | 0.145 | 8.24 (11.25) | 8.93 (10.43) | 0.360 |
IGF-1 (ng/ml) | 240.70 (142.52) | 178.20 (101.15) | 0.059 | 197.21(96.16) | 236.71 (145.99) | 0.418 | 234.43 (144.77) | 208.33 (110.93) | 0.357 |
IGFBP3 (ug/ml) | 3.67 (1.58) | 3.01 (1.35) | 0.061 | 3.31(1.54) | 3.60 (1.56) | 0.448 | 3.58 (1.6) | 3.39 (1.44) | 0.785 |