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Table 2 CXCL9, CXCL10, and IL-18 levels in PBMC Culture supernatants from MAS and FMF patients during active disease

From: Lack of HLH in FMF

 

FMF

MAS

p

CXCL9

(Before IFNγ,)

0.0

(0-13.8)

46.3

(0-152.9)

0.03*

CXCL9

(After IFNγ)

12.20

(0-42.9)

58.9

(0-282.7)

0.11

CXCL10

(Before IFNγ,)

0.0

(0–20)

2.10

(0-40.3)

0.73

CXCL10

(After IFNγ)

0.0

(0-42.5)

28.8

(0–54)

0.31

IL-18

(Before IFNγ,)

73.5

(0-100)

0.0

(0-73.5)

0.91

IL-18

(After IFNγ)

46.8

(0-126.5)

20.1

(0-153)

0.18

  1. MAS, Macrophage activation syndrome; FMF, Familial Mediterranean Fever, IFNγ, interferon-gamma; CXCL, chemokine (C-X-C) motif ligand; PBMC: peripheral blood mononuclear cells
  2. *p < 0.05, statistically significant
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Pediatric Rheumatology

ISSN: 1546-0096