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Table 3 Comparison of geographic distribution, physician and parent/patient reported outcome measures, composite disease activity score and prevalence inactive disease at the cross-sectional visit between children with at least two features among early onset of polyarthritis, ANA positivity, and uveitis and other children with RF-negative polyarthritis*

From: Clinical insights into heterogeneity of rheumatoid factor negative polyarticular juvenile idiopathic arthritis across the world

 

Early onset, ANA positive, uveitis associated polyarthritis

N = 613

Other RF-negative polyarthritis

N = 1384

p

Geographic area (%)

  

< 0.001

 Northern Europe

86 (14.0)

136 (9.8)

 

 Western Europe

63 (10.3)

115 (8.3)

 

 Southern Europe

239 (39.0)

225 (16.3)

 

 Eastern Europe

112 (18.3)

402 (29.0)

 

 North America

31 (5.1)

104 (7.5)

 

 Latin America

39 (6.4)

161 (11.6)

 

 Africa & Middle East

32 (5.2)

210 (15.2)

 

 Southeast Asia

11 (1.8)

31 (2.2)

 

Swollen joint count > 0

248 (40.5)

586 (42.3)

0.460

Tender joint count > 0

204 (33.3)

592 (42.8)

< 0.001

Limited joint count > 0

279 (45.5)

719 (52.0)

0.009

Active joint count > 0

274 (44.7)

665 (48.0)

0.182

Active joint (%)

  

0.002

 Less than 5 active joints

531 (86.6)

1113 (80.4)

 

 5 to 9 active joints

49 (8.0)

142 (10.3)

 

 10 active joints or more

33 (5.4)

129 (9.3)

 

PhGA (median [IQR])

1.0 [0.0, 2.5]

1.0 [0.0, 3.5]

< 0.001

PhGA > 0§

354 (57.7)

932 (67.4)

< 0.001

ESR (median [IQR])

10.0 [5.0, 20.0]

10.0 [5.0, 21.0]

0.445

PaGA (median [IQR])

1.0 [0.0, 3.0]

1.0 [0.0, 4.0]

0.001

PaGA > 0§

359 (59.3)

940 (68.4)

< 0.001

Physical function score > 0†

305 (50.3)

870 (63.1)

< 0.001

HRQoL score > SD 1 in healthy children ‡

3.0 [0.0, 6.0]

4.0 [1.0, 8.0]

< 0.001

Pain intensity (median [IQR])

0.5 [0.0, 3.0]

1.0 [0.0, 4.0]

< 0.001

Pain intensity > 0§

340 (56.1)

908 (66.1)

< 0.001

ACR clinically inactive disease [17]

201 (32.8)

369 (26.7)

0.006

cJADAS10 (median [IQR])

3.0 [0.0, 8.5]

4.5 [1.0, 10.5]

< 0.001

cJADAS10 state (%) [16]

  

0.010

 ID

299 (49.4)

572 (41.6)

 

 MiDA

79 (13.1)

188 (13.7)

 

 MoDA

174 (28.8)

460 (33.5)

 

 HDA

53 (8.8)

155 (11.3)

 

JADI score > 0#

160 (26.6)

452 (32.8)

0.007

JADI-articular score > 0#

121 (20.1)

400 (29.0)

< 0.001

JADI-extra-articular score > 0#

87 (14.5)

163 (11.8)

0.121

  1. IQR interquartile range, PhGA physician global assessment of disease activity, PaGA parent global assessment of disease activity, ESR erythrocyte sedimentation rate, HRQoL health-related quality of life scale, SD standard deviation, ACR American College of Rheumatology, cJADAS10 clinical Juvenile Arthritis Disease Activity Score 10, ID inactive disease, MiDA minimal active disease, MoDA moderate active disease, HDA high disease activity, JADI Juvenile Arthritis Damage Index
  2. *Values are numbers (%) unless indicated otherwise
  3. §Measured with a visual analogue scale on a 21-numbered circle visual analogue scale, ranging from 0 (best) to 10 (worst)
  4. †Score ranges from 0 (no disability) to 45 (maximum disability). ‡Score ranges from 0 to 30, with higher scores indicating worse HRQoL. The SD in healthy children was calculated for each geographical area on questionnaires completed by the parents of these children. #The JADI score is computed only in patients with a disease duration longer than 5 years
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Pediatric Rheumatology

ISSN: 1546-0096