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Table 5 Rituximab vs. cyclophosphamide in the treatment of SLE or AAV

From: Cyclophosphamide treatment with a comparison in both pediatric rheumatology and pediatric nephrology practices

 

Pediatric rheumatologists

Pediatric nephrologists

p-value

n = 56 (100%)

n = 31 (100%)

Would you use CYC and RTX together for induction therapy?

 

 Yes

13 (23%)

5 (16%)

0.360

What drives you to choose CYC or RTX for SLE or AAV?

 Clinical experience

36 (64%)

18 (58%)

0.566

 Efficacy

37 (66%)

16 (52%)

0.185

 Ease of use of the treatment

11 (20%)

8 (26%)

0.505

 Side effect profile

32 (57%)

15 (48%)

0.432

 Availability

27 (48%)

22 (71%)

0.040

 Patient’s age

24 (43%)

14 (45%)

0.835

 Cost

17 (30%)

9 (29%)

0.897

 Patient/caregiver choice

17 (30%)

6 (19%)

0.265

 Disease severity

6 (11%)

6 (19%)

0.263

  1. CYC: cyclophosphamide; RTX: Rituximab; SLE: systemic lupus erythematosus; AAV: anti-neutrophilic cytoplasmic antibody-associated vasculitis