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Table 6 Bivariate analysis of biomarkers and their relationship with bacterial infection in patients with SLEJ and fever (n = 116, Ca = 20, Co = 96)

From: Bacterial infection in patients with juvenile systemic lupus erythematosus and fever

Characteristic and Description

N

Cases

Controls

ORc

95% CI

p-value

PCT > 0.90 ng/mL

 YES

5

4

1

17

1,47 – 1,96

0,02

 NO

21

4

17

ESR > 20 mm/hr

 YES

83

17

66

0,79

0,71 – 0,88

0,12

 NO

14

0

14

CRP > 6 mg/L

 YES

67

13

54

1,27

0,46 – 3,49

0,63

 NO

44

7

37

CRP > 60 mg/L

 YES

25

10

15

5,06

1,79–14,28

0,001

 NO

86

10

76

CRP > 90 mg/L

 YES

13

6

7

5,14

1,50–17,56

0,005

 NO

98

14

84

Ferritin > 500 ng/mL

 YES

22

7

15

2,10

0,64—6,83

0,21

 NO

44

8

36

Consumed C3 (< 88 mg/dl)

 YES

65

14

51

1,48

0,48 – 4,55

0,59

 NO

32

5

27

Consumed C4 (< 15 mg/dl)

 YES

63

12

51

0,90

0,32 – 2,57

0,85

 NO

34

7

27

NLR > 2.0

 YES

77

14

63

1,18

0,41—3,37

0,75

 NO

38

6

32

NLR > 6.0

 YES

30

9

21

2,28

1,05 – 7,88

0,03

 NO

95

21

74

PLR > 132.9

 YES

93

18

75

2,40

0,51–11,21

0,35

 NO

22

2

20

ESR/CRP Index < 2

 YES

60

9

51

0,57

0,19 – 1,66

0,30

 NO

34

8

26

LC4 > 66.7

 YES

73

13

60

0,64

0,20 – 1,85

0,38

 NO

23

6

17

  1. PCT Procalcitonin, CRP C-reactive protein, ESR Erythrocyte sedimentation rate, NLR Neutrophil-to-lymphocyte ratio, ESR/PCR Erythrocyte sedimentation rate-C-reactive protein index, PLR Platelet-to-lymphocyte ratio, LC4 Lymphocyte-C4 index, SLEDAI-2 k Systemic Lupus Erythematosus Disease Activity Index 2000